volatile anesthetics in ischemic liver injury: enemy or friend?
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Volatile Anesthetics in Ischemic Liver Injury: Enemy or Friend?
Implication for health policy/practice/research/medical education: Liver surgery and perioperative care of patients with hepatic dysfunction is still moving toward better safety. Anesthesiologists play their role with judicious selection of anesthetic medications. Ischemic liver injury occurs in a variety of clinical settings such as trauma, shock, and liver surgery (1, 2). Isch-emia and subseq...
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Ischemia-reperfusion injury (IRI) is induced as a result of reentry of the blood and oxygen to ischemic tissue. Antioxidant and some other drugs have protective effect on IRI. In many surgeries and clinical conditions IRI is counteract inevitable. Some anesthetic agents may have a protective role in this procedure. It is known that inhalational anesthetics possess protective effects against IRI...
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(IR) injury can occur under various clinical conditions in which the restoration of blood and oxygen to ischemic tissues results in a massive release of oxygen free radicals. For example, cardiac surgery, stroke, tourniquet application for orthopedic surgery, organ transplantation, and restoration of shock can cause IR injury. Reperfusion produces an increased free radical concentration with li...
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Volatile anesthetics are one class of the most commonly used drugs. However, the mechanisms for these drugs to induce anesthesia are not fully understood and have been under intensive investigation. Two other effects of these anesthetics on the central nervous system, volatile anesthetics-induced neuroprotection and neurotoxicity, currently are hot research fields. Although data from animal stu...
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عنوان ژورنال:
hepatitis monthlyجلد ۱۴، شماره ۶، صفحات ۰-۰
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